Dendrimers branch out to support mucosal integrity
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چکیده
» . . .These studies demonstrate that it is possible to generate synthetic dendrimers capable of interfering with specific residues on innate immune molecules with very profound downstream effects. « Dendritic polymer technology represents one of the most exciting areas at the interface of polymer chemistry and medical science. Dendritic polymers or dendrimers are symmetrical structurally perfect branching molecules synthesized from a central core molecule set, which are classified by the number of branching cycles or generations (Walter & Malkoch, 2012). Dendrimers typically contain a central cavity and beyond three generations, they adopt a spherical configuration. An increasing number of branching generations augment the number of functionalizable groups on the surface available to carry specific molecules or to directly interact with reaction partners. Dendritic polymers may have a range of functional properties including the capacity to function as catalysts, as biosensors or even as anti-bacterial agents. Within biomedicine, dendrimers have been utilized as delivery systems for drugs and in particular hydrophobic agents, radioligands and other imaging molecules. Current research has also focused on dendrimers as vehicles for delivery of DNA with potential for gene therapy. They may be functionalized in a number of ways to improve cellular access through modification or coating
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